Current Knowledge on Bupropion and Varenicline Clinical Efficacy in Nicotine Dependence
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چکیده
The purpose of this paper was to investigate the efficacy of bupropion and varenicline for treating nicotine dependence as reported in the published studies. We analysed 435 journal articles identified in Pubmed data base with “nicotine, dependence, bupropion / varencline” included in abstract. The “human” filter was applied. 20 efficacy studies were selected and included for evaluation in this review. The results of these studies support the efficacy of both bupropion and varenicline, with varenicline showing higher abstinence rates. However in real life settings high levels of efficacy are lacking for all current available treatments. In addition, treatment related side effects highly influence the patient compliance.
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تاریخ انتشار 2015